CPSHAN56 Posted December 12, 2008 Share Posted December 12, 2008 We are currently transfusing ABO compatible cryoprecipitate only. I am aware of a few facilities that only use group A cryo and are transfusing group A to their group B and AB patients. AABB technical manual states, "Because CRYO contains ABO antibodies, consideration should be given to ABO compatibility when the infused volume will be large relative to the recipient's red cell mass." I am looking for additional information, references, experience others have had. Thanks for your help. Link to comment Share on other sites More sharing options...
bxcall1 Posted December 12, 2008 Share Posted December 12, 2008 Our standard dose of cryo is 8 pooled units. Our consideration for ABO type is that our manual states that "we should use ABO compatible cryo, when possible". We have never had an issue using incompatible cryo. Probably due to the small volume, @100ml. Link to comment Share on other sites More sharing options...
bbbirder Posted December 13, 2008 Share Posted December 13, 2008 We don't worry about ABO for Cryo except for the little patients (babies, etc.).Our standard pool is 5. Standard dose is 1 or 2 pools of 5.LF Link to comment Share on other sites More sharing options...
LAS Posted December 17, 2008 Share Posted December 17, 2008 Same here. Link to comment Share on other sites More sharing options...
CPSHAN56 Posted December 20, 2008 Author Share Posted December 20, 2008 Does anyone have additional references to back this practice? I need additional information for my Transfusion Committee. Thank you. Link to comment Share on other sites More sharing options...
ckcheng Posted December 26, 2008 Share Posted December 26, 2008 In addition to Technical Manual, please also seeBlood Transfusion Therapy - A Physician's Handbook saysABO-compatible cryoprecipitate is not required, because of the small amount of plasma, although this volume of plasma may be clinically significant in infnats. In rare instances, infusion of large numbers of ABO-incompatible units of cryoprecipitated AHF can cause hemolysis; a positive DAT can be seen with infusion of smaller doses.Pediatric Transfusion - A Physician's Handbook saysBecause of its small volume, cryoprecipitate does not have to be ABO compatible with the recipient. However, in high-volume transfusions, ABO-incompatible cryoprecipitate may be result in a positive DAT and a risk of hemolysis caused by passive transfer of ABO antibodies. Neonates should be given only ABO-compatible cryoprecipitae because of their small blood volume.Hope this helps.CK Cheng, MSc, SBB(ASCP), CQA(ASQ)Dec 2008 Link to comment Share on other sites More sharing options...
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