Adverse Transfusion Event Case Studies: Part 1, Pulmonary Transfusion Reactions.

[Sherif Abd El Monem]

Adverse Transfusion Event Case Studies: Part 1, Pulmonary Transfusion Reactions
eLearning in Transfusion Medicine-New York Blood Center Enterprises

https://immunohematologymadeeasy.com/adverse-transfusion-event-case-studies-part-1-pulmonary-transfusion-reactions-nybce/

[Neil Blumberg]

While it is infrequently referenced, universal leukoreduction is one strategy for minimizing pulmonary and cardiovascular adverse responses to transfusion (see attached).  When we instituted it in 2000 our rate of TRALI decreased by 80+ % and TACO decreased by 50%.  Probably mechanism is that white cells, DNA, histones and neutrophil extracellular traps (NETs) cause acute lung injury and inflammation when infused (good animal model data exist).  Thus the failure to implement universal leukoreduction in the USA during the last 23-25 years was a terrible and tragic mistake, and this fatal error persists to this day.

ULR TRALI TACO PMC version.pdf

[Sherif Abd El Monem]

On 6/22/2023 at 4:59 PM, Neil Blumberg said:

While it is infrequently referenced, universal leukoreduction is one strategy for minimizing pulmonary and cardiovascular adverse responses to transfusion (see attached).  When we instituted it in 2000 our rate of TRALI decreased by 80+ % and TACO decreased by 50%.  Probably mechanism is that white cells, DNA, histones and neutrophil extracellular traps (NETs) cause acute lung injury and inflammation when infused (good animal model data exist).  Thus the failure to implement universal leukoreduction in the USA during the last 23-25 years was a terrible and tragic mistake, and this fatal error persists to this day.

ULR TRALI TACO PMC version.pdf 334.17 kB · 1 download

Thank you, Dr. Neil, for your valuable comment.