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Showing results for tags 'antibodies'.
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Okay so I was always taught to use the rule of 3, 3 positive reactions and 3 negative reactions for peforming an antibody ID. I was also taught to always use homozygous positive and negative cells whenever possible. Sometimes of course it is not due to low incident/high incident antigens. I do know you need to use a homozygous cell when performing "rule outs". What is everyone else's practices and thoughts as I need to clarify our current antibody identification policy. Thanks in advance. -
There are a number of well-read (and well published) posters here. I am wondering if any of you know what the most common cause of equivocal reactions that come upon during antibody ID? You know, the often weak reactions that are left over after all of the rule-outs are accomplished? Some are apparently the result of HLA interactions, but are most just junk reactions with otherwise unnamed insignificant antigens? More importantly, how many are actually "developing" antibodies to significant antigens? We do see, over time, patients pop up with only a few equivocals, and after a few transfusions, develop a full response to a significant antigen. I was just wondering if there is any data on how commonly this occurs. Thanks, Scott -
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