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VPearce

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  1. Thanks
    VPearce got a reaction from Malcolm Needs in Gold Medal.   
    Congratulations!
  2. Like
    VPearce reacted to Cliff in Applied Blood Group Serology, 4th edition,by Issitt and Anstee   
    I'll sell one for $749 USD.
  3. Like
    VPearce reacted to Malcolm Needs in Applied Blood Group Serology, 4th edition,by Issitt and Anstee   
    My own copy is signed by both authors.  How much is that worth????????!!!!!!!!!!!!!
  4. Like
    VPearce reacted to Malcolm Needs in Weird type   
    There is a way of confirming it by genoty[ing, but it would cost the Earth for very little return.
    I would like to know how old is the patient and what is the underlying pathology?
    You have to remember that the the A, B and H antigens, in common with other carbohydrate-based red cell antigens, are not direct gene products, simply because only proteins can be direct gene products, whilst sugars cannot.  In the case of an AB individual, at least two different transferase enzymes are responsible for conferring either the N acetyl-D-galactoseamine residue, in the A antigen, or the D-galactose residue, in the case of the B antigen.  These two enzymes are in direct competition with one another as to which one "wins the race" to convert the H backbone to either A or B; sometimes the "A transferase" wins, and sometimes the "B transferase" wins.  In this case, it could be that the A-transferase is winning "hands down", and that the B-transferase is "whimping out a bit"!  Sorry, that last bit wasn't written exactly scientifically, but I hope you understand what I mean!
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