We accept non-group O directed donors, but we perform a full crossmatch. We actually require a full crossmatch on group O directed donors too because of any antibody to a low frequency antigen the Mother may have made to the newborns red cells (new Dads frequently want to donate for their newborns and would pose an increased risk). The problems of parent donations are listed in many places in the publication on Pediatric Transfusions by the AABB. Mothers donating for their kids (if enough time has elapsed since delivery) pose an increased TRALI risk. But we do allow it if the MD and parents insist.