We, in the deep south, were told to ONLY use CPDA-1 units for neonates. The majority of our babies needing blood are 22-26 weeks. The super low birth weight can't allow any Adsol (well, I think it is 1 cc per kilogram of birthweight and these babies are maybe 400-500 grams...kinda pointless.)
As for filters...our NICU does the filtering of all products. We send an aliquot of whatever the NICU needs, in a bag with about 10 cc extra for priming tubing. They filter using a Hemonate filter, which gets down to 17 microns. With LBW premies, you have to be super careful about what may get through a 170 micron filter and cause respiratory distress or stroke.
As for products, we keep a docked CPDA-1 LR, CMV negative O neg rbc for its life. We try to manage lowest donor exposure, if possible. For FFP, always AB...aliquot and go on. The remainder is going to expire in 24 hours (we use it for QC.) As for platelets, we try to get type specific. No joy...whatever is available (catch-22) We request docked, LR, CMV negative. Then, we pull into aliquot bags. We don't have a sterile docking device and with money troubles, will never see one.
I know the LR and CMV negative are somewhat redundant, but it is what my medical director and neonatologists have agreed on. Until I can convince them otherwise, I will continue as is.
As for worry about "D"...our understanding is "until baby is 4 months old, baby is unable to develop ANY antibodies." That is why we will transfuse baby based on Mom's antibody screen (if negative.) If Mom is positive, we test baby until baby is negative, then start testing again at 4 months of age.
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