I will start the ball rolling with how we handle some of the issues you have addressed: 1. Antibody is present, but not ID'ed yet, and crossmatch is compatible: We have a form that states that the antibody has not been identified, and although the crossmatch is compatible transfusing it does carry some increased risk because it has not been screened for the corresponding antigen. Ordering physician has to sign the form. (Pathologist is not usually notified.) 2. Patient has a history of a clinically significant antibody and the crossmatch is compatible: We have a form that states that, plus the comment that transfusing it does carry some increase risk because it has not been screened for the corresponding antigen. Ordering physician has to sign the form. (Pathologist is not usually notified.) 3. Antibody is present, but not ID'ed yet, and crossmatch is incompatible: We have a form that states that the antibody has not been identified and the crossmatch is incompatible and carries an significant risk of a possible hemolytic transfusion reaction. Ordering physician has to sign the form. Pathologist is notified that we are issuing incompatible blood. The above situations are spelled out in our policies/procedure manual. In any of the above situations, if the supervisor or assistant supervisor is present they are consulted and get involved in the situation (to make sure we are doing the best/safest thing for the patient.) If supervisor or assistant supervisor are not present, whether they are consulted/notified depends on the expertise/experience of the tech involved. All staff are certainly welcomed to call us at any time, but a few of our experienced techs are comfortable handling the situation. Donna