Pathogen inactivation

[AMER]

Dear ALL ,

I want to know the difference between Intercept treatment and Mirasol treatment for Platelets and Plasma (Pathogen Inactivation) .

 

Regards

Amer 

[kate murphy]

Different photo-reactive chemicals.  Intercept = amatosalen, Mirasol = riboflavin.  Both activated by UV light to cross link DNA/RNA sections to inactivate proliferation of bugs/white cells.  Lots of info with google...

[Eman]

Another important difference, at least in the US, is that INTERCEPT is approved/licensed for use with platelets and plasma but approval to use Mirasol in the U.S. is still pending (The Terumo website says Mirasol is "available in select markets". We went live with INTERCEPT for platelets earlier this year, been a generally positive experience. Downsides have been mostly related to collection targets (there are somewhat strict acceptance parameters for volume, platelet concentration and platelet content that required us to tweak our collection targets a fair bit) and the system isn't licensed for triple products, so we can only collect and process single and double collections.  We had previously irradiated all of our platelets, so it was a nice benefit to no longer have to irradiate once we implemented INTERCEPT.

[AMER]

Thanks a lot all for your replay and your comments what about the technique and the time of processing also the cost ,what is the difference between all of theme ?    

 

Regards

Amer