suhu Posted September 28, 2007 Share Posted September 28, 2007 My question is directed at those of you doing electronic crossmatching. In our instituion, patients with positive antibody screens due to "clinically not significant (CINS)" antibodies qualify for electronic xm. Some of these antibodies are IgM's, others are who-knows-what. But other times, CINS present as a "real" antibody on subsequent workups, or the patient just develops a real antibody in addition. We have a fairly high number of "clinically not significant" antibody screens with our automated testing (who-knows-what). For patients with positve antibody screens due to a previous identified CINS, we are debating doing panels each time vs. full AHG crossmatches. The situation is frustrating, as the idea behind the CINS was to allow electronic crossmatching when insignificant antibodies such as Lewis, cold autos etc... ,are present. However, with automated testing, the antibody screen will often be postive in these cases. I'm interested in knowing how often you are repeating panel work-ups in this situation (CINS)? Do you do full crossmatches on all these patients also? Link to comment Share on other sites More sharing options...
janet Posted September 29, 2007 Share Posted September 29, 2007 Don't you have to do a full crossmatch any time an antibody is present (whether it is clinically significant or not)? Link to comment Share on other sites More sharing options...
suhu Posted September 30, 2007 Author Share Posted September 30, 2007 we are not required to do full crossmatches unless there is a history of, or a current, clinically significant antibody.a patient qualifies for an electronic crossmatch if the antibody screen is positive, but the identitfied antibody is not clinically significant. I'm just curious what others are doing. Since there is no serologic crossmatching, how often are antibody workups being repeated in these situations? Link to comment Share on other sites More sharing options...
Cathy Posted October 4, 2007 Share Posted October 4, 2007 If we are not sure what the antibody is, we assume it may be clinically significant. We do IgG crossmatches on these patients. If the antibody screen comes up positive we repeat the panel; every three days if need be. If the patient has a history of an NSA (non-specific antibody), and the screen is now negative, we still do IgG crossmatches. Link to comment Share on other sites More sharing options...
rcurrie Posted October 4, 2007 Share Posted October 4, 2007 We crossmatch through AHG if there is any problem with the compatibility testing. BC Link to comment Share on other sites More sharing options...
John C. Staley Posted October 10, 2007 Share Posted October 10, 2007 Bob, I think that's the shortest response you've ever given. If we get "who-knows-what" antibodies we will try to identify everytime we get a positive screen with this patient. It is not unusual for an antibody early in it's develpment to not really know what it's going to be when it grows up so the next time you test the patient the antibody may have had time to mature into it's recognizable state. Link to comment Share on other sites More sharing options...
LABKING Posted November 13, 2008 Share Posted November 13, 2008 (edited) try other methods , other reagents, and storage of reagents may make a difference, think out of the boxlike gel igg cards work better stored at room tempetcotherwise, we do what Cathy does, Igg xmatch, gives us peace of mind Edited November 13, 2008 by LABKING Link to comment Share on other sites More sharing options...
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