staceydg Posted April 3, 2007 Share Posted April 3, 2007 Hi All! I work at a Blood Donor Center. We routinely use Immucor reagents and have recently experienced some discrepant test results from donation to donation using the A1 Lectin. Has anyone else been having this issue? Also, we recently had two donations where the donor was determined to be Rh negative on the first donation and then was picked up as weak D on the second donation. Of course I was quick to assume tech error the first time, but after some investigation and some industry buzz I think others may be having the same experience. Any thoughts? Link to comment Share on other sites More sharing options...
OPUS104 Posted April 4, 2007 Share Posted April 4, 2007 Hi Stacey. Do you Rh manually (prob. not) or use a system like the PK? We sometimes have this Rh problem using the PK 7200....but I think it is a dilution study problem. Link to comment Share on other sites More sharing options...
staceydg Posted April 4, 2007 Author Share Posted April 4, 2007 We use the Rosys, but manually perform weak D testing on all donors. In addition we perform ABO/Rh confirmation on all first time donors. Link to comment Share on other sites More sharing options...
rcurrie Posted April 5, 2007 Share Posted April 5, 2007 I have a couple of weak D positive donors who will type as Rh negative one time and Rh positive the next time. It all depends on the cutoff for that particular run. It is no big deal- we call the donor Rh positive based on history.BC Link to comment Share on other sites More sharing options...
Mabel Adams Posted April 5, 2007 Share Posted April 5, 2007 Wouldn't it be a slightly big deal if the D neg test happened to be the first one done on that donor--at least for the recipient of that supposedly Rh neg unit? Link to comment Share on other sites More sharing options...
rcurrie Posted April 5, 2007 Share Posted April 5, 2007 I have had that situation before also, Mabel. I have never had a patient seroconvert from receiving such a unit. The FDA isn't worried about it, the patients don't seem to react to them, so it seems to be a reasonable risk as with any serological test. You win some, you lose some. I no longer get excited when it happens.BC Link to comment Share on other sites More sharing options...
OPUS104 Posted April 9, 2007 Share Posted April 9, 2007 We currently only draw and process about 350 units a day at our donor center. We ABO on the PK7200 and have had a problem with first time Rh neg. donors repeating pos. on subsequent donations. We currently manually test all first time Rh negative donors. For a long time we did not worry too much about these "repeat weaks" (been like that since I came here), but revisited that policy recently and felt it would be best to change it. In answer to your original question........we have not had a problem with our Immucor A1. Link to comment Share on other sites More sharing options...
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