Do you give CDE neg units when the patient has anti-D.

[gonneb25]

Currently, we always give CDE neg red cells to patients with anti-D. This used to be easier when the reagent company sold anti-CDE. Now it is backordered so we are using anti-C and anti-E. My question: are most hospitals providing CDE neg units? And, are most places screening units for patients exhibiting anti-D due to RhIg? We currently screen the units, but only perform ISXM's as the antibody was passively acquired. I am thinking of going to ISXM's of unscreened units for the RhIg patients. Thanks for your input.

[bevydawn]

We do not currently screen units for C or E when a patient has anti-D. Giving Rh negative units should decrease your odds of getting a C or E positive unit and we just take our chances of the patient developing the C or E. And that has only happened very few times over the past several years. So obviously we do not screen units for patients that have a passively acquired anti-D. All we do for them is an AHG crossmatch until the anti-D is no longer present.

[Lcsmrz]

We do not screen for C or E as well when transfusing someone with Anti-D. And other than residual RhIg, we're seeing less and less patients with an Anti-D, usually very old females.

[John C. Staley]

Same here. We don't routinely screen for C & E just because someone has an anti-D.

[Cathy]

Same here!

[adiescast]

We do not worry about the C and E until they show up. As was already noted, Rh negative units tend to be negative for C and E anyway. So far, we have not noted a problem with this. The only time we have been prophylactically C and E typing units is for sickle cell patients, regardless of whether they have anti-D.

[gene20354]

Same here.