Posted June 17, 20232 yr comment_85959 Adverse Transfusion Event Case Studies: Part 1, Pulmonary Transfusion Reactions eLearning in Transfusion Medicine-New York Blood Center Enterprises https://immunohematologymadeeasy.com/adverse-transfusion-event-case-studies-part-1-pulmonary-transfusion-reactions-nybce/
June 22, 20232 yr comment_85980 While it is infrequently referenced, universal leukoreduction is one strategy for minimizing pulmonary and cardiovascular adverse responses to transfusion (see attached). When we instituted it in 2000 our rate of TRALI decreased by 80+ % and TACO decreased by 50%. Probably mechanism is that white cells, DNA, histones and neutrophil extracellular traps (NETs) cause acute lung injury and inflammation when infused (good animal model data exist). Thus the failure to implement universal leukoreduction in the USA during the last 23-25 years was a terrible and tragic mistake, and this fatal error persists to this day. ULR TRALI TACO PMC version.pdf
June 23, 20232 yr Author comment_85987 On 6/22/2023 at 4:59 PM, Neil Blumberg said: While it is infrequently referenced, universal leukoreduction is one strategy for minimizing pulmonary and cardiovascular adverse responses to transfusion (see attached). When we instituted it in 2000 our rate of TRALI decreased by 80+ % and TACO decreased by 50%. Probably mechanism is that white cells, DNA, histones and neutrophil extracellular traps (NETs) cause acute lung injury and inflammation when infused (good animal model data exist). Thus the failure to implement universal leukoreduction in the USA during the last 23-25 years was a terrible and tragic mistake, and this fatal error persists to this day. ULR TRALI TACO PMC version.pdf 334.17 kB · 1 download Thank you, Dr. Neil, for your valuable comment.
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