We've noticed that Kidd antibodies are not being enhanced by the Ortho ficin treated panel cells (multiple lot #s of panels and gel cards). For weak Kidds, the untreated panels are often reactive, while the ficin treated panel is nonreactive. Ortho's package insert recommends using buffer gel cards with the ficin treated cells (Provue will only perform the ficin panel with buffer cards loaded). After further investigation, we've discovered that performing the ficin panel with IgG gel cards (manually) provides the expected enhanced Kidd antibody reactions. Bottom line, buffer cards are not working according to the manufacturer for Kidd antibodies. Whether the Kidd Ab IgG component structure isn't buffer gel sensitive, Ortho won't speculate. Nor has Ortho admitted to any other record of this occurance. Has anyone else noticed this phenomenon? Beware