MAGNUM

Hi justme,
 
Well, the thing is that, in effect, we do not perform titrations on plasma from pregnant women containing either anti-D or anti-c, but, instead, perform dilutions and compare these against a national standard anti-D or anti-c by way of quantification in a continuous flow analyser (hence, for example, 20 IU/mL, rather than a titre of, for example, 256).
 
You can see the way we do this in a Powerpoint lecture in the Library called "Allo-immune haemolytic disease of the fetus/newborn HDF/HDN."
 
We maintain that, once the maternal anti-c has reached a level of 20 IU/mL (and, assuming, of course, that the fetus is expressing the c antigen on its red cells) there is a very high risk of hydrops without fetal medicine intervention.  In most cases, this will involve an IUT.
 
From then onwards, until delivery, we will test the woman's plasma, as a minimum, every 2 weeks until delivery to ensure that she has made no other antibody specificity, and to keep an eye on the level of the anti-c.  That having been said, in some new guidelines, about to be published in the UK, once the fetus is being monitored by MCA Doppler, it has been decided that there is no necessity to monitor the level of the anti-c (or anti-D), as the fetus will then be monitored directly by MCA Doppler, rather than indirectly by antibody level.
 
I hope all that helps!

Do you have access to AABB.org?  They have an HCV lookback packet with some form letters.  If you will search for HCV lookback letters you can find the packet.

WE DO NOT, REPEAT DO NOT ACCEPT ANY TYPES FROM ANY OTHER FACILITY. Too many times we get types that disagree with what we get, and it is because they are sent to reference laboratories (not bb reference labs Malcolm), where there are upwards of 2000 - 3000 types done daily, so there will be mistakes. So long and short, I dont accept them.