Liz0316

Wow, I'm jealous. I have made a power point where I have assigned human characteristics to the antibodies, example, FY are soldiers and JK are covert spies...etc. But no one has seen it yet....and I can't sing!

If your patient has not been recently (or ever) transfused an auto adsorption can be done. I like to get a baseline adsorption even if the patient has never been transfused. I want to see  negative cells somewhere. So, if your screens, panels and elutions are all positive, and you suspect an auto antibody, I would perform one (or send to reference depending on time of day!) Once established that the patient has no allo antibodies and then is transfused, I look at reactions for the next time they come in. Has it only been a few days? are all reactions even and the same strength? It's always best to get diff adsorptions within 3 months of transfusion, but I also realize that may not always be possible. Sometimes your crossmatches will give you the answer. I have found that a XM using 4 drops of plasma and no enhancement (inc 30 -60 min) will depict a compatible XM. Remember your auto antibodies are far more fragile than the allos. An allo antibody will react (at some strength) especially if incubated at 60 min. However, back to patient safety...do the auto adsorption first, then get diff adsorptions done on a weekly basis. That's what we do - unless it's an extreme emergency of course.

If your patient has not been recently (or ever) transfused an auto adsorption can be done. I like to get a baseline adsorption even if the patient has never been transfused. I want to see  negative cells somewhere. So, if your screens, panels and elutions are all positive, and you suspect an auto antibody, I would perform one (or send to reference depending on time of day!) Once established that the patient has no allo antibodies and then is transfused, I look at reactions for the next time they come in. Has it only been a few days? are all reactions even and the same strength? It's always best to get diff adsorptions within 3 months of transfusion, but I also realize that may not always be possible. Sometimes your crossmatches will give you the answer. I have found that a XM using 4 drops of plasma and no enhancement (inc 30 -60 min) will depict a compatible XM. Remember your auto antibodies are far more fragile than the allos. An allo antibody will react (at some strength) especially if incubated at 60 min. However, back to patient safety...do the auto adsorption first, then get diff adsorptions done on a weekly basis. That's what we do - unless it's an extreme emergency of course.