Hi Liz, Based on your post #25 above, I think that all of the statements are in agreement. Per Standards, A platelet containing 2 mL of RBC or more requires a crossmatch (note that even a D+ unit would be compatible if the patient has not made anti-D). According to my experience, a clear, yellow component contains less than approximately 0.2 mL of RBCs. The Technical Manual states that, a platelet may contain enough RBCs to stimulate an immune response in some patients. If you chose NOT to issue Rh immune globulin and the patient develops anti-D, what do you do? For any subesquent RBC transfusions, they would only get D-negative AHG-crossmatch compatible units. If you transfuse a platelet that contains 0.2 mL of D+ RBCs to a patient who has anti-D, will they develop any adverse symptoms? I really don't know.