Keeping in mind that thought that each facility has it's unique situation, am sharing some observations using Monoclonal IgG. We implemented Monoclonal IgG not long sfter it first came out...and yes it was a relief not having so many "cold" antibodies showing up at coombs, requiring panels! We had AOT! Down the road tho, we still has "stuff" showing up at coombs very weakly that was indeterminate. After much investigating this issue, we determined it was unique situation involding HIV/AIds patients. We had ALOT of those kind of patients. Since their autoimmune system is totally shot, we also figured out over 17 years, we never had one AIDs patient ever develope a clinically significant antibody! Just sharing some info that might be useful!