Amy Jagger

It is most unlikely to be anti-f, as this specificity will not react with either R1R1 or R2R2 red cells (I presume that you are using both antibody screening cells and antibody identification panel cells that have these phenotypes represented).

Anti-f reacts with red cells where the c and e antigens are the result of an RHCE*ce haplotype where, for want of a better way of putting it, the c and e antigens are the result of the RHc and RHe genes being in the cis position - NOTE THAT THIS TERMINOLOGY IS (KNOWINGLY) WRONG!

Like all Rh antibodies, anti-f reacts most strongly with its cognate antigen on red cells that have been treated with a proteolytic enzyme (such as papain or ficin), but will very often react with untreated red cells by IAT.

My immediate thought is that they should have sent the sample on to Red Cell Reference at the IBGRL.

If they have also detected an antibody by IAT and enzyme techniques, that is not reacting with autologous red cells, and, as the DAT is negative, the specificity needs to be sorted out as early as possible in the pregnancy, in case the antibody is 1) clinically significant and 2) becomes more potent during the pregnancy.

Hi Amy
Feel free to ask questions.  This is very good sites to share BT knowledge. The best person for this topic is Malcolm Needs as you can see in threads. 
Good luck 

A little bit late into the forum, but I am currently completing the HSD in transfusion and also in the process of trying to find others that have or are completing this course to keep in touch, as I am the first within my department to complete this! 

Thank you all for the welcome! 😁 

Thank you all for the welcome! 😁