We have an interesting case that we could use some help on. We have a patient that has been getting transfusions for the past two years for anemia. No known cause for the anemia per the physician. Last week, he came in and screen adn crossmatches all neg. About 50 cc's into the transfusion, he spiked a fever. They stopped the unit and transfusion reaction workup was normal, including culture and gram stain.(no growth even after 5 days). They started the second unit after giving tylenol and Benadryl, about 15 cc's into the unit, he spiked a fever again. He walked out AMA after second reaction. Again everything normal. Today he came back in and his sample is icteric(previoulsy it was not). We did DAT, screen and full crossmatches. Everything is negative. According to the physician, there is no reason clinically why he should be hemolytic, nor does he have any known liver problems. They still want to transfuse tomorrow. Any ideas on why his serum would suddenly be icteric?