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Mrmic, are you saying that a prestigious an institution as the British Committee for Standards in Haematology is wrong in this recommendation? - Quote " Routine irradiation of red cells for transfusion to preterm or term infants (other than for EBT) is not required unless there has been a previous IUT". Even though they reviewed relevant publications over an eleven year period? Note it is only a recommendation.

On p. 563 of AABB Tech Manual 18th edition, it only mentions that titer methods other than "saline AHG 60 minute incubation" in tube may result in higher titers and "should be validated with clinical findings" (see Malcolm's post, above). So it does not seem to say one cannot use gel or other methods, just that you need to document validation. I have always been a bit uncomfortable with identifying an antibody with gel (for a prenatal), then doing the titers in tube. But then again, I guess it is the comparison of the series of tube titers that they are looking at. Scott