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I need some guidance! I did a quick search of the forums for any discussion about this, and the most current posting was in 2010. I'm wondering if anyone has any new information, new experiences, or any advice about CAP TRM.40120. The note states "...all analysts participate in QC on a regular basis." How frequently is "regular"? For example, when I was looking to complete our annual Competency assessment in September (don't ask...), I was looking for evidence that each individual who performs MTS testing had performed MTS QC. There were some employees who had not performed MTS QC yet in 2016. I'm inclined to say that someone who hasn't performed QC in at least 8+ months is not participating in QC on a regular basis. Being new to my role, I'm just not sure how the assessors interpret this standard, and how others provide evidence of compliance.

Yes, as there are times when the causative antibody is an IgM (such as anti-Vel), and, never forget, the titre of the anti-Vel may be VERY low, but the complEment system is an amplification system (i.e. one C1qrs complex will result in huge numbers of other activated complement molecules further down the line), but you can concentrate the eluate and be able to detect the antibody originally sensitising the red cells. The antibody can also be a VERY weak IgG antibody (IgG1 or IgG3, or a mixture), and the same applies.