Anti-S

[christyn]

Has anyone ever heard of a naturally occurring Anti-S similar to naturally occurring (that is not a result of immunization) Anti-E?

[Malcolm Needs ☆]

I have never seen one myself, but Geoff Daniels cites two papers in his book Human Blood Groups 2nd edition, Blackwell Science 2002, which are as follows:

Coombs HI, Ikin EW, Mourant AE, Plaut G. Agglutinin anti-S in human serum. Brit Med J 1951; i: 109-111.

and

Constantoulis NC, Paidoussis M, Dunsford I. A natuirally occuring anti-S agglutinin. Vox Sang (old series) 1955; 5: 143-144.

Good luck to you if you try to hunt down these papers!

These two papers are also quoted by Peter Issitt and Dave Anstee in Applied Blood Group Serology, 4th edition, Montgomery Scientific Publications 1998.

Good luck if you decide to hunt these papers down!

From this, therefore, I would say that, yes, "naturally occuring" anti-S does exist, but that it is exceptionally rare (or, alternatively, it is not so rare, but that people have just not written up cases).

:)