GP.Mur (Mi. Ⅲ) can be called Chinese blood do? Prepared AB-type anti-Mur standard serum.

[sunan20090128]

GP.Mur (Mi. Ⅲ) can be called Chinese blood do? Prepared AB-type anti-Mur standard serum.

Recently, we found one cases of AB-type blood donors, serum containing anti-Mur, therefore, carried out a number of plasma exchange to prepare a batch of anti-Mur standard serum. The anti-Mur is very valuable because the AB-type non-ABO antibodies in human serum, so it can be used as determining human red blood cell Mur antigen'santibody reagents. It can be used as populations red blood cell GP.Mur (Mi. Ⅲ) phenotype frequency of the investigation.

The cases of IgM anti-Mur has passed the international authentication.

Anti-Mur is an important Miltenberger blood group system antibodies, our preliminary experiments showed that in southern China, anti-Mur frequency of 0.11% (15/14210), red blood cell Mur antigen frequency of 6-7% . Anti-Mur is the world's largest number of irregular antibodies in the Chinese.

Question 1: GP.Mur (Mi. Ⅲ) can be called Chinese blood do?

The general international transfusion medicine community, said Miltenberger blood group antigens and antibodies for the "low frequency", it seems that the Chinese are not the low-frequency, because the population frequency of 6-7% GP.Mur positive close to the AB-type ABO blood group frequencies. So, name given GP.Mur (Mi. Ⅲ) phenotype of the Chinese red blood cell, as if some sense.

Question 2: Why is China Mur antigen-positive blood donors in north and south such a big difference in the rate?

In southern China, red blood cell Mur antigen (GP.Mur) positive 6-7%. However, in northern China, such as the Shanghai blood donors Mur antigen positive rate 0.5% (15/2970). What has caused the North and the South China Mur antigen-positive blood donors in such a big difference in the rate, who can in theory explain?

Thanks

Would welcome further research cooperation.

SUN Ai-nong (Director, Professor)

E-mail: sunainong@21cn.com

[TimOz]

Hi Sunan,

The prevailing theory is that Glycophorins on the red cell surface act as receptors for malaria parasites. Genetic variations of the glycophorin molecules MAY be protective. If you look at the MNS variations they are in areas where malaria has been (rather than is now). As examples the Taiwanese Ami have the highest rate of GP.Mur and they were a coastal people even though they tend to be called "the Hill people". Vw in the northern Europeans especially Dutch where it was low and wet and Malaria was endemic. MARS in the Chocktaw Indians from the Mississippi area of N. America. High incidences in South Asia (wet and more tropical) and lesser incidences as you go North.

Not proven but sounds reasonable.

[Yanxia]

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I am very interesting in your post , but I just know Chinese and English.