blood for anemia

[irshadaad]

hi all....i want to know if we should give blood units reactive for G6PD and sickel cell to the pts with ANEMIA ( chronic/sevear),if no why if yes why....usualy our practice is restrict these units from given to peads ,neonates ,and animic pt,wanna know reason why

[Malcolm Needs ☆]

hi all....i want to know if we should give blood units reactive for G6PD and sickel cell to the pts with ANEMIA ( chronic/sevear),if no why if yes why....usualy our practice is restrict these units from given to peads ,neonates ,and animic pt,wanna know reason why

Hi irshadaad,

If I understand your question correctly, you are asking if the blood from a donor who is G6PD deficient or who is HbS positive can be used to transfuse a patient who is anaemia? If I am correct, the answer depends upon why the patient is anaemic in the first place.

In the UK, we will accept a donor who is, for example HbAS, but will not accept a donor who is HbSS, on the grounds that the latter will be medically unfit to be a donor. Having taken this donor's blood, we are quite happy to give this unit of blood to a patient who is, for example, anaemic because they have an anaemia due to a chronic bleed, but would not give it to a patient who is anaemic due to sickle cell crisis, or is a sickle cell patient who is being "topped up" prior to flying (where they will be exposed to an environment that may be lower in oxygen content than would be "normal").

We would also not give such blood to a paediatric or neonate patient because the oxygen carrying capacity of the donor red cells would be considerably less than that of a donor who is HbAA (it must be remembered that the neonatal patient's body, in particular, is used to being "supplied" with oxygen from red cells that are predominently HbFF). The HbAS donor's red cells would, physiologically speaking, regard the neonates circulation as an environment "starved" of oxygen, and would not, therefore, give up its oxygen easily to the tissues (which is what is, after ali, the raison d'etre for the existance of red cells.

HbSS donors would be turned down on medical grounds, on the basis that they need their blood more than do other patients(if you see what I mean).

To a certain extent, the same arguements apply to a donor who is G6PD deficient, except that the UK would almost certainly exclude such donors from giving blood in the first place on medical grounds. That ahving been said, unless the patient is exposed to, for example, fava beans post-transfusion, and unless the percentage of circulating G6PD blood is high after transfusion (as it probably would be in a neonate or paediatric patient) then it should be okay.

I hope I have gone some way to answering your question, but I'm absolutely certain other people could answer your question better than have I; but it's a start!!!!!!!!!!!!!!!!!!!

:redface: