???Antibodies associated with a reactive RPR

[johna]

We are a reference laboratory performing >100 antibody IDs a week and deal almost exclusively with prenatal patients. We've consistently noted what seems to be a significant correlation between the presence of very weakly-reactive Coombs antibodies which defy identification and the presence of false-positive reactive RPRs.

Some time ago I posted an inquiry on the AABB website and the only feedback that I received was from someone who recalled reading that the antibody involved in this phenomenon seemed to be directed against lipids on the red cell membrane as opposed to a specific red cell antigen. I've not been able to get any further information on this but was wondering if anyone else has had similar experiences and/or may know of any publication reference for this. Thanks in advance!

[L106]

Interesting.