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gagpinks

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Everything posted by gagpinks

  1. Thanks Malcolm RCI suggested xm compatible blood but when I was reading articles, they were saying it's clinical significant, which confused me more.
  2. Patient has anti Cob reacted by enzymes IAT. Is this clinically significant antibody? Does this patient require antigen negative blood?
  3. Thanks everyone Clinician hasn't suspected transfusions reaction and hasn't asked for any investigations. This is something we noticed the results when they requested further blood unit. just wanted to know causes of DAT to be positive in C3d therefore shared on discussions board.
  4. Hi we had patient who has known anti E antibody. He has been transfused with 2 units E- K- by IAT xmatch. 2 weeks iater we received sample for G/S and request for 1 unit of blood due to low Hb. However clinician haven't suspected any transfusions reaction. Performed antibody screen and found to be positive with Anti-E and Jka with DAT positive in IgG 1+ and C3d 2+. Would this be a transfusion reaction? Or patient had developed new antibody due to recent transfusions? What is reason for DAT to be positive in C3d as well? I think IgG antibody causes extracascular haemolysis . Is it due to antibody develop recently that might be IgM in nature ? Thanks in advance
  5. Is this mean autoantiboody absorbed better with Rh antigen? I am also trying to understand how RCI deal with pan-reactivity especially with HFA
  6. Thanks Malcolm I just wanted be assured. Our SOP suggest it is good laboratory practice to get new sample after 2 units of platelet transfusions however i don't see any benifits if patient need regular platelet transfusions especially haem patients
  7. Hi All If patient has 2 known historical blood group, do we still need valid group and save at time of platelet transfusion? I am trying to find out in guidelines but unable to find. If patient is on regular platelet transfusion how often should we repeat group and save and why?
  8. Hi We perform DAT using polyspecific AHG card which detect IgG and/or C3d. If DAT is positive then we use monospecific card which detect DAT is positive due to IgG or c3d or both. This card also has control. Control must be negative.
  9. You are well deserved for this.
  10. we did try this but apparently, it works very weekly than expected.
  11. As Bankergirl mentioned you can use IAT method to confirm. But it will not differentiate between partial D and weak D
  12. gagpinks

    Anti-Inb

    Hi I was reading articles on social media regarding 2-year-old girl developed anti-Inb ( In a news article from the USA). She has neuroblastoma and difficulty finding Inb negative blood. If a patient is on chemotherapy and required regular transfusion it is hard to provide blood in these situations. How severe anti-Inb can cause transfusion reactions especially when a patient is on chemotherapy? Can she have ABO and D compatible blood with methylprednisolone?
  13. Reviewing this process so just wondering did you use any control with this process? Do we need to run control ? Can't find in guidelines
  14. This could be due to anti c IgM in nature. I have seen this many time especially in pregnant lady.
  15. Do you run any control with this process ? With IAT crossmatch we use OR1r cell with weak antiD.
  16. Hi Does anyone use immediate spin method for crossmatch? Do you require any control in this process? I personally don't prefer this method especially when you have robust IT system and 2 sample policy.
  17. Hi thanks for your reply First Virginia then after while probably Texas
  18. Another interesting similar case. In this case antibody screen negative in first pregnancy and also negative at booking blood in second pregnancy. Repeat antibody screen at 28 weeks found to be positive with anti-c . There is also additional reaction detected in reverse group probably due to Anti- c IgM in nature . Send sample to RCI and quantification level is 37.2 IU/ml and followed repeat testing in 2 weeks went up to 56. Clinician decided to induce her at 36 week. First baby was Rh negative now just waiting for baby to born. Hope baby is not r'r . Otherwise it will be real challenging scenario.
  19. Thank you for your reply. I guess i was being over cautious. We trust RCI result but my worry was if we x match at our hospital it will be definitely incompatible (2 or 3+). I was over thinking that we could have missed out low frequency antibody. Just out of curiosity if we perform x match at RCI do you treat Donor cell with DTT. Of just issue least incompatible unit.
  20. Thank you galvania. But what does your lab usually in terms of X match. Because if we perform xmatch its seems pointless because it would be positive. How can we ensure that units are compatible?
  21. If patient is on Dara is it safer to ask reference lab to perform X match or we can x match onsite once it's confiremed by RCI that there is no underlying alloantibody.
  22. I guess it's applies for transfusions as well. If I want to work in blood bank do I need to pass any exam ?
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