I understand that the gel IgG crossmatches cannot adequately detect ABO incompability per manufacturer's instructions and regs, but what about using the electronic controls of a validated system to detect ABO incompability in addition to the gel crossmatch? AABB Standard 5.15.1 states: “The crossmatch shall use methods that demonstrate ABO incompatibility and clinically significant antibodies to red cell antigens and shall include an antiglobulin test.” My opinion: electronic controls monitor ABO incompability and clinically significant antibodies. Check. IgG crossmatches are an antiblobulin test. Check, check. Standard met.
I understand that the gel IgG crossmatches cannot adequately detect ABO incompability per manufacturer's instructions and regs, but what about using the electronic controls of a validated system to detect ABO incompability in addition to the gel crossmatch? AABB Standard 5.15.1 states: “The crossmatch shall use methods that demonstrate ABO incompatibility and clinically significant antibodies to red cell antigens and shall include an antiglobulin test.” My opinion: electronic controls monitor ABO incompability and clinically significant antibodies. Check. IgG crossmatches are an antiblobulin test. Check, check. Standard met.