We have no rules set up for our hematology qc. I do look at the levy-jennings to identify shifts or trends, but generally speaking rules like 10x or 4,1s aren't very helpful. In the world of hematology, being part of a qc pool is the most important tool (for Beckman users, it's IQAP). Comparison of your values to the "pool" is much more important than package insert means. Having multiple instruments is also helpful for comparison. We run a patient check once a day - i have 3 instruments, so at any given time, between IQAP reports and patient check numbers i can figure out which instrument is showing a problem. Because our standards in NY require at least one level of control every 8 hours, +/- 15 minutes(!) we have taken to running one level of control every 6 hours - it is actually saving a lot of money (we were running 2 levels every 8 hours). If there's ever a problem with the one level of control, they can run the other levels as a troubleshooting measure. Hope that helps!