Malcolm Needs
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Everything posted by Malcolm Needs
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MicroLabTalk: Staphylococcus aureus
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General Lab: Kwashiorkor (IV)
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General Lab: Kwashiorkor (III)
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General Lab: Kwashiorkor (part II)
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Welcome Bmiller
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General Lab: Kwashiorkor
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Suspected Anti-D + Anti-C vs. Anti-G: Separation/Differentiating Difficulty — Has Anyone Seen Similar Results? Case Comparisons? Thoughts...
Thank you for your exceptionally kind words DLabGirl, and by all means use the lecture as you wish. The same goes for anyone else who might want to use it, with the proviso that you a) realise that it is a bit "long in the tooth", and b) I did mean that we, in the UK, would still look to ensure that there really is an anti-D present, before we do not recommend giving anti-D immunoglobulin.
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General Lab: Kuru disease
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Welcome Jessica Howell
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Suspected Anti-D + Anti-C vs. Anti-G: Separation/Differentiating Difficulty — Has Anyone Seen Similar Results? Case Comparisons? Thoughts...
In the UK, we would test serum/plasma samples from pregnant patients to see if there was an anti-C + Anti-G, or an anti-G on its own, but if the tests showed an anti-D+C, we didn't go any further to see if there was an anti-G there as well. I mean, what for? What difference does it make? I attach a PowerPoint lecture on the subject I wrote some years ago, but I think it is still pertinent. The G Antigen and Anti G.pptx
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General Lab: Spermatozoa
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Welcome Darin
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HemeLabTalk: Cancer Cells
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General Lab: Immunity
THANKS Cliff.
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General Lab: Immunity
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General Lab: Immunity
I wonder if there is something wrong here Cliff. I am convinced that I hit the button for the correct answer - and I see that nobody else has got it right yet either?
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Welcome R.Eng
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Welcome cafrazier
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- Forward and reverse blood grouping in a donor centre
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Forward and reverse blood grouping in a donor centre
In the UK a unit of blood would NEVER be sent out to a hospital without a full (and matching) ABO type - both forward and reverse. We would also do everything possible to ensure that, if the forward and reverse ABO types of any patient do not match, we find out why before transfusion. An ABO mismatch is probably the most common cause of fatal haemolytic transfusion reactions (although, thank goodness, they are NOT common), and this is why we will always go "the extra mile" to try to prevent any such situation.
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Welcome FAD
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Welcome Pmcgovern
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MicroLabTalk: Cholera
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MicroLabTalk: Mycobacterium
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Source of advice on transfusing patients with mismatched stem cell/bone marrow transplants?
Sorry Neil, but I have to point out that this is not completely accurate. Any red cell antigens that are adsorbed onto the red cell surface, rather than being an integral part of the red cell membrane remain the type of the patient, rather than the donor. This is true of the Lewis phenotype (for instance, if the recipient was Le[a+b-], and the donor was Le[a-b+], after the transplant, the red cells will group as Le[a+b-], and not as Le[a-b+]}. This is also true of antigens within the Chido/Rodgers Blood Group System, and certain others. If the recipient is a Secretor, they will continue to secrete ABO substance of the original ABO type, which, of course, will also be adsorbed onto the red cell surface (as well as being in the plasma, leading to the phenomenon of "accommodation", and this is why most recipients stay with a reverse group of "AB" after an ABO mis-matched stem cell/bone marrow transplant. SORRY TO BE A PEDANT, PARTICULARLY AS I AGREE WITH EVERYTHING ELSE YOU HAVE WRITTEN!