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Malcolm Needs

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Everything posted by Malcolm Needs

  1. Malcolm Needs
    Welcome mirta gamez.
  2. Malcolm Needs
    Welcome Erin Graves.
  3. Malcolm Needs
    Welcome jsbneg. Are you? If so, you are very rare!
  4. Malcolm Needs
    Welcome exotich.
  5. Malcolm Needs
    Welcome Dbug26.
  6. Malcolm Needs
    I am still a member of the aabb, the ISBT and the BBTS, and so receive all of their journals, AND also get the American Red Cross's Immunohematology journal. I LOVE reading through them. I also still lecture a bit and, of course, am on here. This all keeps me mentally stimulated.
  7. Malcolm Needs
    We normally used a ratio of 1:1, unless the antibody was particularly weak, in which case we would, on occasions, go up to 4 of plasma/serum to 1 of red cells in NISS (BUT, make sure that such a ratio is written into your SOP).
  8. Malcolm Needs
    Welcome Lorna Middleton.
  9. Malcolm Needs
    Welcome Asif Dawar.
  10. Malcolm Needs
    Welcome noora.
  11. Malcolm Needs
    I cannot find the reference for which I was looking, and I wonder if (now I am in my dotage) I have mis-remembered and that it was one of a couple of papers stating that IgM ABO antibodies are easier to inhibit than are IgG ABO antibodies. The references for these are Witebsky E. Interrelationship between the Rh system and the ABO system. Blood 1948; 3: 66-79, and Kochwa S, Rosenfield RE, Tallal I, Wasserman LR. Isoagglutinins associated with erythroblastosis. J Clin Invest 1961; 40: 874-883. My apologies.
  12. Malcolm Needs
    Welcome txlabtech.
  13. Malcolm Needs
    How do you get hold of the extremely rare antibody specificities I mentioned (such as anti-Vel) to regroup units sent from, possibly, frozen blood banks, that they have typed as Vel Negative before the unit is sent out?
  14. Malcolm Needs
    Somewhere, in Patrick Mollison's work, cited in Blood Transfusion in Clinical Medicine, he mentions that IgG ABO antibodies are more clinically significant in solid organ transplants than are IgM (if I remember correctly, he specifically mentioned renal transplants), but I cannot cite the exact paper off the top of my head (I will see if I can find the reference). As a result, whenever we were dealing with a renal transplant that crosses the ABO barrier, we almost performed an IgM and an a separate IgG titre. Whether this is now considered to be necessary, I will leave to other people to discuss!
  15. Malcolm Needs
    Welcome krb212.
  16. Malcolm Needs
    I did allo-adsorptions on eluates for quite a while and never once detected anything in the adsorbed eluate. My own experience suggests that it is a waste of time and resources, but others may disagree.
  17. Malcolm Needs
    Welcome Louiserioux.
  18. Malcolm Needs
    Welcome cgrig.
  19. Malcolm Needs
    Welcome Don Wilson.
  20. Malcolm Needs
    Apart from me, is anyone else missing the ability to see who has a birthday on a particular day, or am I just a sentimental old fool in a minority of one???????????
  21. Malcolm Needs
    Hmmmmmmmmmm, that makes life more difficult! If the mixed-field reactions were only seen in the ABO typing, that would be fairly easy to explain. As they are in the Rh type as well, the explanation may be much more difficult, not least because Rh antigens are proteins, and so are fully expressed at birth. I just wonder if, in the cases you see, there is a noticeable difference between the D type of the mother and the baby. For example, is the mother D Positive and the baby mostly D Negative, with just a few D Positive red cells in evidence? This could be explained by there having been a foeto-maternal haemorrhage, largely from the maternal circulation to the foetal circulation. Obviously, If the mother is D Negative and the baby types mostly as D Positive, with just a few D Negative red cells in evidence, the same applies. Am I going completely down the wrong street?????????????
  22. Malcolm Needs
    Is this ABO typing, or other typing?
  23. Malcolm Needs
    Welcome memiiller,
  24. Malcolm Needs
    Welcome Pathtech07.
  25. Malcolm Needs
    Welcome Glenn Mason.
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