Hi All
Historical A POS (never phenotyped) no antibodies detected. MDS patient, multi-transfused with APOS/NEG units over past 3 months.
Results
Screening cells (using BioRAD 3 cells) +2 positive reaction only with R2R2 (cell II). DAT +2 (IAT method/ IgG/C3d polyspecific)
Panel negative which suggested a low prevalence/frequency/incidence antibody however - crossmatch was positive which led the question was there was another underlying antibody ( a soup of antibodies).
Reference Lab Results
Possible Jka by IAT enzyme and non specific enzyme reactions. Now awaiting genotyping.
Advise to crossmatch Rh/K/Jka D-C-E-Jka-
My question is now the patient has returned to group A POS (there was a dual population before with the D type due to the previous transfusions)
is it acceptable to transfuse D+ (as historically RhD+) C-E-Jka- units or could there be a potential D typing anomaly ?
Thanks