We are writing a new cryo SOP ....our facility hasn't stock it in the past. thought I had it nice and simple, included the "Suggested Adult Flow Rates" from AABB,then a question popped up... Dr wanted to know how to calculate how many units to give? Pt in question is vWD, (unsure if they'r Type 1,2 or 3), slow abd bleeding We rec pooled units from our supplier ( 1 pooled unit = 5 single untis) The tech did a good job of researching it but the math looks cumbersume, and there are multiple formula. What do others do....if anything? Our local university said: give 2 pooled units for an adult, and a 3rd if they need it. A provider on line organization said: same as above AABB : dose(untis) = (Desired fibrinogen increment in mg.dl) X plasma volume (dL) / 250 mg /unit Circular of information (2009) : for fibrinogen: # of bags = 0.2 X body weight in kgfor Factor VIII: # of bags = desired increase in F8 level in % X 40 X body weight in kg/average units of F8 per bag. Circular of Information (2013) : for fibrinogen: # 1 bag per 7-10 kb body wt t raise plasma fibringon by apporx 50-75 mg/dLfor Factor VIII: # of bags = desired increase in F8 level in % X 40 X body weight in kg/average units of F8 per bag. ????????????? hope I transcribed the formula correctly