I agree with all the above we have used O pos on all our massive transfusion patients and on any emergency release blood given to a male or female >50. We also use A FFP in any emergency release or massive transfusion patient. The only problems that we have run into as with any massive transfusion patient is how late we get the T/S and then the patient shows as an O pos and then after being in the hospital a while starts to show their true type. As far as antibodies, in an emergency situation there are risks, but death is what we are trying to prevent. We have not had very many patients that come back with antibodies and Anti-D isn't even usually the one made. More often than not it is a K or Duffy, possibly a Kidd.