yiams
Reputation Activity
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yiams got a reaction from Malcolm Needs in Use of Plasma to Treat Angioedema RXN from Ace Inhibitor
Several years ago (circa 2005) we had two sisters who would report to ER for anywhere between 8 and 12 units of FFP to treat their hereditary angioedema. Their symptoms were facial and airway swelling. We treated them as genuine emergency situations whenever they appeared. They had a brother who asphyxiated due to the disease. No recombinant product or other purified C1 esterase inhibitor product was available to us. The plasma worked but we were always worried about volume overload. No adverse effect was ever reported to us. We did discover that the sisters had been enrolled in a trial for some sort of inhibitor replacement product. They felt that it did not work so they came to us for plasma infusion.
When our in-house transfusion guidelines were first developed we were instructed to use freshly thawed plasma, not 5-day thawed plasma, for these patients. Our pathologist had a reference but I'd have to do some digging to find it.
There have been several angioedema-related articles published in _Transfusion_ over the years. They have mainly been related to hereditary forms or acquired forms (but not drug-related, to the best of my recollection). Have not heard about this in relation to ACE inhibitors, however.
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yiams got a reaction from Teristella in O neg with Ant-c?
I'm a little late to the party because my wife and I were on holiday. This post caught my attention because we had an O neg patient with allo-anti-c at our facility in 2015. I've attached a .pdf write up I summarized for our CLS students and any generalist in our laboratory who were interested. This is based on the patient history we could acquire and reports from our reference laboratory and the Blood Center of Wisconsin.
Del Type.pdf
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yiams got a reaction from goodchild in O neg with Ant-c?
I'm a little late to the party because my wife and I were on holiday. This post caught my attention because we had an O neg patient with allo-anti-c at our facility in 2015. I've attached a .pdf write up I summarized for our CLS students and any generalist in our laboratory who were interested. This is based on the patient history we could acquire and reports from our reference laboratory and the Blood Center of Wisconsin.
Del Type.pdf
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yiams got a reaction from Malcolm Needs in O neg with Ant-c?
I'm a little late to the party because my wife and I were on holiday. This post caught my attention because we had an O neg patient with allo-anti-c at our facility in 2015. I've attached a .pdf write up I summarized for our CLS students and any generalist in our laboratory who were interested. This is based on the patient history we could acquire and reports from our reference laboratory and the Blood Center of Wisconsin.
Del Type.pdf