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missyg

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    missyg got a reaction from carolyn swickard in DTT-Treatment of Screening Cells (Daratumumab/Darzalex)   
    Because the technical Manual does state packed cells we now use donor cells for DTT treatment. We have found that we get better results than the DTT treated reagent cells. The reagent cells seem to lyse more and we have had to repeat testing a lot because of that.
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    missyg reacted to Malcolm Needs in Anti-M quandry Looking for feedback   
    Geoff Daniels quotes no less than 7 papers in the 3rd edition of his book Human Blood Groups. They are:
    Yasuda H, Nollet K, Ohto H. A review of hemolytic disease of the fetus and newborn due to MN incompatibility in Japan. Vox Sang 2009; 97 (Suppl. 1): 125 (Abstract).
    Stone B, Marsh WL. Haemolytic disease of the newborn caused by anti-M. Br J Haematol 1959; 5: 144-147.
    Macpherson CR, Zartman ER. Anti-M antibody as a cause of intrauterine death. A follow-up. Am J Clin Path 1965; 43: 544-547.
    Yoshida Y, Yoshida H, Tatsumi K, et al. Successful antibody elimination in severe M incompatible pregnancy. New Eng J Med 1981; 305: 460-461.
    Duguid JKM, Bromilow IM, Entwistle CD, Wilkinson R. Haemolytic disease of the newborn due to anti-M. Vox Sang 1995; 68: 195-196.
    Furukawa K, Nakajima, T, Kogure T, et al. Example of a woman with multiple intrauterine deaths due to anti-M who delivered a live child after plasmapheresis. Exp Clin Immunogenet 1993; 10: 161-167.
    Kantra T, Yuce K, Ozcebe OI. Hydrops fetalis and intrauterine deaths due to anti-M. Acta Obstet Gynecol Scand 1996; 75: 415-417.
    Hinchliffe RF, Nolan B, Vora AJ, Stamps R. Neonatal pure red cell aplasia due to anti-M. Arch Dis Child fetal Neonatal Ed 2006; 91: F467-F468.
    Wikman A, Edner A, Gryfelt G, Jonsson B, Henter J-I. Fatal hemolytic anemia and intrauterine death caused by anti-M immunization. Transfusion 2007; 47: 911-917.
    Geoff speculates that anti-M could have a similar aetiology to anti-K, in that it attacks very early erythroblasts, leading to a sort of suppression of erythropoiesis, hence the neonatal pure red cell aplasia.
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