Yes, we have had issues with missing Kell antibodies using Capture-R and when done by the MTS Gel Method, no problem. Today we had a positive antibody screen with Capture-R and when we ran the ID panel, the tech could not figure it out. I thought perhaps it was a anti-Jka but it missed 2 homozygous Jka cells on the panel. We then ran the screen and antibody ID using the MTS Gel Method. No problem. Reacted with all the homozygous and heterozygous cells. I repeated the few cells missed on Capture-R and they repeated negative. I am not sure what is going on. When I did my validation when we first got Capture-R it was definitely more sensitive than the MTS. But now it seems...????questionable. We use the 3-5% Ortho Screening Cells, which doesn't have the enhancement media that the Panel A 0.8% does. My techs are losing faith. I am currently doing a whole new validation. Not happy at all. Heather