Thank you all for your thoughtful responses.  Much appreciated!

Hello all,

Any truth to the maxim which I've inherited in my training which is that anti-Jka can do funny things on the panel?  e.g. react with heterozygous donors and then not react with homozygous donors?  React inconsistently?

Not sure if this lore can be confirmed by others ...

Thanks!

Thank you.  Makes sense! 

Hello all,

If you had a patient who appeared to have anti-D and anti-C and titers between the two were quite discrepant, is that sufficient evidence to effectively confirm anti-D?  This assumes that anti-G, if present, would react with cells containing the C or D (and G) antigens with similar titer (which I do not know to be true, but perhaps someone on here does know this).  Perhaps the G antigen is represented in different quantities on RhD vs C antigen bearing cells ....

Thank you! 

Hello all,

Any differences between Ortho Panel A versus Ortho Panel B which would argue that a CLS should favor (from a serology perspective) using Panel A first to work up an antibody ID (as opposed to using Panel B first)?  I imagine that if you statistically rule out your antibodies using either Panel, you should be good.  But, perhaps there is a nuance I am missing.

Thanks!

As per the title ... is there any particular MNS (or other) phenotype that is most ideal for performing a titer of anti-Ena during pregnancy?

Thank you!