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HPLC - 20% peak in HbA1C window


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We are considered a high risk area for haemoglobinopathies and use the TOSOH for our HPLC antenatal screening. If we get a peak over 6% in the HbA1c window we check to see if they are a known diabetic. If they aren't we notify our consultant biochemist who issues a 'new diabetic' report.

 

Recently I was running the samples and got an A1C of 20%, which is pretty much unheard of, so we sent it away for confirmation. It came back as a Haemoglobin South Florida and is clinically insignificant.

 

Just thought I would share as it's not one I've seen before.

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