epfeiffer Posted April 11, 2012 Share Posted April 11, 2012 We currently do not label FFP collected from CMV sero-negative donors as CMV negative, the working theory (I assume) is that the low temperatures required for the freezing and storage of FFP kill or inactivate the virus. Recently we've had two customers question this decision. I cannot find any literature discussing this specific issue, does anyone have any information regarding CMV and FFP? Link to comment Share on other sites More sharing options...
SMW Posted April 12, 2012 Share Posted April 12, 2012 From the Circular of Information:"Transmission of CMV disease is associated with cellular blood components. Plasma, cryoprecipitate, and other plasma-derived blood componets do not transmit CMV; therefore, CMV testing is not required for these components." Link to comment Share on other sites More sharing options...
epfeiffer Posted April 12, 2012 Author Share Posted April 12, 2012 Does this take into account the fact that our plasma is not necessarily leukocyte reduced? Or does this even matter? Link to comment Share on other sites More sharing options...
SMW Posted April 12, 2012 Share Posted April 12, 2012 Leukoreduction does not matter. Frozen plasma is considered an acellular product. Similar analogy for why frozen and then thawed plasma does not need to be irradiated for those individuals at risk for graft-vs-host disease. heathervaught 1 Link to comment Share on other sites More sharing options...
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