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Cold Agglutinins and Auto Donors


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We had a patient the other day come in for autologous donation with a very strong cold agglutinin. The CBC tube had to be incubated for around an hour to get a valid H & H. My question is: what effect will this cold agglutinin have on this donor's autologus unit which will be in cold storage for at least a week? Can it simply be reinfused through a blood warmer which will allow the agglutination to disperse or will the unit be unable to be infused?

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  • 2 weeks later...

Our facility is 100% leukoreduced. When we get a cold Auto with an autologous unit, it of course does not filter. We inform the receiving hospital and let them decide if they want to try and get the unit to go through a transfusion set. Most of the time, we send these units as unfiltered red cells.

I have seen some of these look normal after warming............but not many. (How effective can this unit be after going through all of these changes?)

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