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Everything posted by ziya
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historic blood group is old(30 years with forward only), and prepared red cells of the patient with bromelin and find no change of reaction pattern of red cell antigens,so it is not aquired antigen or Tn activation.
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sorry for confusing,of course there is no anti-A2 ,I would have to say that what the shily is, reaction with the A2 cells.There are number of questions to be answered. 1. I will find out the exact time of the historic blood group of the patient,if its an old history it could not be due to cancer 2.I think most of us use monoclonal reagents,but on literature reactions patterns usually belong to polyclonal antigens,so we get confused.
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sorry for confusing,of course there is no anti-A2 ,I would have to say that what the shily is, reaction with the A2 cells.There are number of questions to be answered. 1. I will find out the exact time of the historic blood group of the patient,if its an old history it could not be due to cancer 3.I think most of us use monoclonal reagents,but on literature reactions patterns usually belong to polyclonal antigens,so we get confused.
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Infact in serum of the B(A) phenotype we can see anti-A1 (very rare) but not the anti-A2 ,is there any report contrary,so the only explanation is an acquired red cell antigen A in a patient with the cancer.
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what kind of antibody you have?If it is against your red cell antigens its called auto, if it is not, we call it as alloantibody, there are mix cases also,keep in mind in IVIG transfusion you can get it passively,if this is the case its a temporary but ifnot its always permanent.
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may be the answer is: Incompatible A expression Expression of `A-like antigen' in tumors of O individuals is observed less frequently than deletion of A or B determinant in A or B tumors (i.e. tumors from blood group A or B individuals). This phenomenon, termed `incompatible A expression,' is another long-standing problem in human tumor immunology, since tumor cells expressing A-like antigen in O or B individuals could be a target of host immune surveillance at the early stage of human cancer development and are more likely to be immunologically rejected. Incidence of tumor occurrence in blood group A individuals compared to O individuals was higher for gastric cancer (1.21) and ovarian cancer (1.23), clearly higher for vulvar cancer (1.39) and much higher for salivary gland cancer (1.55) [96]. A-like antigen was once considered to be an Across- reacting antigen .. S.-i. Hakomori / Biochimica et Biophysica Acta 1473 (1999) 247^266
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we used two diffent anti-A reagents,both of them was mouse monoclonal(Immucor,Tulip) with completely different types of clones.We havent human anti-A at the moment.
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A and B antigens on red cells is not weakened, another possibility may be Tn
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62 male with pancreas CA,no history of transfusion,previous blood group(historic) was AB anti-A 4+ anti-B 4+ anti-AB 4+ A1cell 4+, A2cell 2+, Bcell negative, Ocell negative, Autocontrol negative,DAT negative, IAT negative,IAT(room)negative,slide anti-a4+,slide anti-B4+, AB XM incompatible,B XM compatible, O XM compatible, any suggesting wellcome