hello every body..few days a go we had this case and i would like to share it with all of you, we might find something to help this patient; We have 14 years old female patient with AML, she was receiving a lot of products lately , but 3 days ago once she relived the blood few minutes later she developed Transfusion reaction, we did all the work up nothing wrong except that we found her post and pre DAT positive and IgG and C3d negative, she developed fever, techacardia and hypotension. the next day she received FFP 2 units , and platelets no problem the day after she received PRBC again the same symptoms..and they stooped the transfusion immediately. ( fever, hypotension and tachycardia...etc) We did all transfusion reaction work up this time..the same except that we have IgG and C3d positive, so we did Elution but its negative. The 3 screening cell is positive only the AC is negative. In immediate spin cross match nothing is compatible...so what do you think about that is TRALI, TACO or just febrile Reaction , and what is the way to solve it? Thanks and happy holiday…