Hi there,
The chances of an "acquired antigen" due to some intestinal problems like malignancy or sepsis, are theretically right. But I understand that the artificial antigens will not be picked up by the newer generation antisera which are monoclonal. The earlier versions of antisera, which were polyclonal, used to give "positivity" for both natural and "artificial antigens". But in this present, where majority use monoclonal antisera, such problems and complications are extremely rare.
The present problem of "A or O " could have been sorted by the Blood Bank by comparing the grouping results using a "parallel run" with monoclonal and polyclonal antisera. .....
In addition, where there is a discrepancy like this, any sensible Blood bank would like to go by the rule "PLAY SAFELY"...and use "O group " Blood for transfusion if necessity comes.
best wishes...