Hello, Our facility has been using the Echo for about 5 months, in recent months we have had issues with the Select plate for AHGXM. Immucor has distributed a communication that they are aware that sometimes a screened unit is giving an unexpected positive result with the Capture-R Select. We have had 5 such patients, antibody identification is complete, units are screened but crossmatch is incompatible. We have checked the units for positive DAT, re-checked the antigen testing and sent some of the specimens to Immucor (which repeated the same on their analyzers). The AHGXM was performed in gel and tube for these patients and found to be negative. During validation of the Echo and since we have detected antibodies that were not seen in gel or tube. I am reluctant to just perform AHGXM in another method without using the same method that was used for antibody identification. At the same time Immucor is aware there is an issue and we are wasting time screening additional units that will potentially be compatible in their system. How are others dealing with this issue? Thank you.