Hi , we have in the last couple of weeks had two cases of patients with anti-c , reacting with the A cells of the blood group, i have never saw this before ( only the usual cold reacting antibodies such as Anti-M etc)  and was just wondering if this is something that others experience and why this is happening? The supplier has confirmed that the A cells are A neg (rr) cells. 

 

 

Thanks

Tricia 

Hi Tricia,

It isn't actually that uncommon a phenomenon, and is due to the anti-c being, at least partially, IgM in nature.

Most of the common Rh antibodies have been reported as IgM. A "saline-reactive" anti-E is probably the most often seen. I've personally seen an anti-e that appeared to be IgM.

Way back when, in the dawn of time........there was serious concern over examples of IgM anti-D potentially causing ABO reverse typing discrepancies - hence why the commercial reverse calls are all Rh-.

Thanks for the responses

Hi Malcolm, not sure if you remember but I spoke to you at Scotblood this year!

 

tricia

2 hours ago, NAN47 said:

Hi Malcolm, not sure if you remember but I spoke to you at Scotblood this year!

I do indeed Tricia, and it was a real pleasure!

likewise Malcolm, always nice to put a face to a name