We typically type for anti-c when a patient comes up with Anti-E, is it necessary to do for Anti-E when the patient has anti-c?

We type for C,E,c,e every time a patient has an Rh antibody.

41 minutes ago, kimblain said:

We typically type for anti-c when a patient comes up with Anti-E, is it necessary to do for Anti-E when the patient has anti-c?

Technically, its not "necessary" to do either....

But to answer your question: No.  

A patient who has developed anti-E has a high chance a having been exposed to the c antigen.  That is why "some practitioners" recommend typing for c, and if the patient is negative, giving c- and E- units even if the anti-c is not present.  This practice is not a requirement!  

The same is not true for a patient who has anti-c; the chance of being exposed to the E antigen are less, so this situation is not treated in the same manner.

Right, I agree with Steven.  The E-c- phenotype is relatively common. If someone is producing anti-E, with more transfusions, they are likely to eventually produce anti-c  unless that is screened for as well on the units.  Not so for other combinations.

Scott

If a patient has any Rh-antibody, we give them Rh-typed blood. Such as patient has anti-E and pheno is E-, e+, C+, c-, K-, we give E-, c- and K- blood. But if the patient is only E- (others positive) we notify E only. So based on phenotyping. 

That's a lot of antigen typings...

 

Scott

In the UK, EVERY unit is typed for C, c, E, e and K (as well as ABO and D of course!), so it would be no problem for us.  It may be the same in Finland?????????????????

Sorry for late answer! 

In Finland every donor is tested for ABO RhD and K. Other phenotypes are marked on the unit after tested two times (two donations). The most commonly tested other phenos are Rh CcEe, then comes Kidd, Duffy MNS (perhaps around 3000 donors/year) and C^w and for the last but not least C^x, Ul^a and Lw^b (plus ~100 donors/year are tested for Ls^a, An^a and WES^a). 

That might sound a lot but we have centralized our production into one place in Finland. Donating sites are all over but blood products are only made, supplied and delivered from one center that is situated in our capitol. Small country