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comment_63988

As Mabel Adams once posted, you rule out the presence of anti-K1 every time you do an antibody screen and there is no agglutination of the screen cell that is K+k+!

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  • Malcolm Needs
    Malcolm Needs

    Hi Scott, I can understand that, if the anti-Lua can be detected, you give cross-matched compatible blood. If your screen is negative, and your three Lu(a+) red cell samples give a positive result,

  • If the antibody screen is negative, regardless of whether there is a Lua positive cell on the screen or not, we would give AHG compatible XM units and never look back. 

  • I would not think that you would have to run other rule outs and  I wouldn't bother testing 3 Lua+ cells, just 1 would do. Some labs would not confirm at all and just go right to AHG compatible blood.

comment_63991

On the original discussion, the whole question becomes moot if you allow rule outs with the same criteria as you do with your negative antibody screens--one homozygous cell for most, 1 hetero for K.  The rule of 3 came about for improving statistical accuracy when identifying antibodies, not for ruling them out.

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