Hi Malcolm

 We have a case where 32 year old pregnant lady Oneg rr and her partner is R2r. Her antibody screen was negative  at 12 weeks, she has been given prophylactic anti-D at 19 weeks,  Now her antibody screen is Positive and look like she developed Anti-D(proph D) and Unexplained anti-C.

As far as we know this is her first pregnancy and no previous miscarriage or no transfusion history. How did she develop anti- C?Are Anti-D injection  pure anti-D or they can contain mixture of Rh antibody? Do you think anti-C could have come from Prophylactic anti-D injection.

Hi Malcolm

 We have a case where 32 year old pregnant lady Oneg rr and her partner is R2r. Her antibody screen was negative  at 12 weeks, she has been given prophylactic anti-D at 19 weeks,  Now her antibody screen is Positive and look like she developed Anti-D(proph D) and Unexplained anti-C.

As far as we know this is her first pregnancy and no previous miscarriage or no transfusion history. How did she develop anti- C?Are Anti-D injection  pure anti-D or they can contain mixture of Rh antibody? Do you think anti-C could have come from Prophylactic anti-D injection.

Yes, we see passive transfer of Anti C every once in a while with Rhophylac.

Once in a while we outdate a vial of Rhophylac so I dilute it a bit and give it to the students to do a panel. Panel always shows anti-D+C

Thanks everyone for replying,much appreciate! !

In this case do you think we should flag this patient for Anti-C?

Thanks everyone for replying,much appreciate! !

In this case do you think we should flag this patient for Anti-C?

Thanks everyone for replying,much appreciate! !

In this case do you think we should flag this patient for Anti-C?

We send the sample for titres and again for a second time. If the titre is falling, we suggest that it is due to the Rhophylac, if rising, immune

Please see my reply to this post in the other question posed.