Oh, Most Knowledgable Blood Bankers....

Is there a reference for the answer to this question?

A unit of frozen plasma (FFP or FP24HR) expires at midnight. It is thawed at 2200 hours on the day it would expire. Usually, thawed FFP or FP24 is good for 24 hours from the time of thawing.

Is the expiration of the thawed product 2400 (midnight) or 2200, the next day (24 hours)?

This is NOT a 5 day plasma question ;-).

Thanks in advance, Bill

I believe it would be 24 hrs from time of thaw or the original expiry of the product, whichever is sooner.

I believe it would be 24 hrs from time of thaw or the original expiry of the product, whichever is sooner.

Agree.

same here. 24 hrs from the time of thawing.

24hrs from time of thawing...

Oh, Most Knowledgable Blood Bankers....

Is there a reference for the answer to this question?

A unit of frozen plasma (FFP or FP24HR) expires at midnight. It is thawed at 2200 hours on the day it would expire. Usually, thawed FFP or FP24 is good for 24 hours from the time of thawing.

Is the expiration of the thawed product 2400 (midnight) or 2200, the next day (24 hours)?

This is NOT a 5 day plasma question ;-).

Thanks in advance, Bill

For a reference see 21CFR610.53(

.

"When the dating period begins. The dating period for a product shall begin on the date of manufacture, as prescribed in § 610.50. The dating period for a combination of two or more products shall be no longer than the dating period of the component with the shortest dating period."

So the expiration date of the thawed product cannot be longer than the expiration date of the frozen product. In the example you provided, the thawed product would expire in 2 hours (2400) when the frozen product would have expired.

Sorry for my ignorance. Yes in your case it would be midnight because the expiration time of FFP is shorter then 24 hrs.

same here. 24 hrs from the time of thawing.

Expiry date and time comes before the allowed 24 hours of storage for FFP in ths case so: at midnight the same day it is no longer considered FFP (after thawing).

If you keep it beyond expiry it is as per AABB standards applicable to liquid plasma:

"Liquid Plasma. Store at 1-6 C. Expiration: 5 days after expiration of Whole Blood. 21 CFR 610.53©applies"

if in fact your unit expires on said date, and you thaw it on same said date, the unit would expire at midnight despite the fact that you have 24 hours for thawed ffp.

Agree with mhc, 24 hours or original expiration date, which in this case is shorter

You cannot extend an original outdate whether you are thawing, pooling, irradiating or anything else.

 

It is always 'whichever comes first', the original outdate or the 'new' outdate.

It would expire at midnight. Test your LIS to make sure this works; we found a glitch years ago in Sunquest that it would extend it to 24 past the midnight expiration...yikes. It's been fixed since then.