Hi Everyone

We have an AB neg patient that is platelet dependant Our blood centre cannot supply us with AB neg plts so our patient has been receiving A neg pools instead. If this patient requires a blood transfusion and there is no AB neg rcc's available, which blood group would be the 2nd choice to transfusion i.e A neg or B neg rcc's. Does the decision depend on the number and blood group of the platelets previously transfused to this patient in the last week?

thanks

I think this would depend on your plt issue . . . if you give mostly A plts I'd give A rbcs.

I think this would depend on your plt issue . . . if you give mostly A plts I'd give A rbcs.

Agree. Besides the fact that A Negative units will likely be more readily available than B Negative units.

Thanks

Is this covered in any published guidelines or is this just best practice?

Common sense I think.

Margaret Ann,

You may find some difinitive answers through researching the relative Ab concentrations of Anti-A from a B donor and Anti-B from and A donor, and also research the respective concentrations of IgM and IgG of each; in addition to availabilty of products where you are located.

Having spent many happy (???????????) hours titrating ABO antibodies for making human ABO reagents in my youth (long before monoclonal antibodies were even a twinkle in the eyes of Cesar Milstein and Georges Koehler), I can confirm that the anti-A in group B subjects is usually of a higher titre than the anti-B in group A subjects - but you always get the odd individual who's immune system has not read the books!!!!

Margaret Ann,

You may find some difinitive answers through researching the relative Ab concentrations of Anti-A from a B donor and Anti-B from and A donor, and also research the respective concentrations of IgM and IgG of each; in addition to availabilty of products where you are located.

Thanks rravkin

Thanks for that Malcolm

American Red Cross has a chart in their blood transfusion guidelines that states that the second choice PRBC for an AB patient would be A and the third choice B. Hope that helps.

American Red Cross has a chart in their blood transfusion guidelines that states that the second choice PRBC for an AB patient would be A and the third choice B. Hope that helps.

And the same above 1st choice A and then B , it is mantioned in AABB

( chapter 20# Hemotherapy Decisions and Their Outcome)

(Table 20-4 , page 576 , 16th edition)

And more is Malcolm Needs already explained

So there you have it, in addition to the vast knowledge of the people on this site, both the ARC and AABB say the same thing.